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Is Ketogenic Diet Really Good?
Aug 13, 2018

There is a very popular ketogenic diet, a low-carbohydrate, high-fat diet plan that has long been considered to help lose weight and is highly regarded. But a new study, recently published in the Journal of Physiology, found that ketogenic diets, while contributing to weight loss in the short term, may increase the risk of developing type 2 diabetes early in the diet.

Ketox diet and type 2 diabetes

Type II diabetes is one of the most pressing challenges of our time, and the ultimate cause is not fully understood. Insulin resistance means that insulin is released from the blood and involved in the regulation of blood sugar levels, and also sends a signal to the liver to stop the secretion of sugar. Once this system is damaged, the body will not be able to use insulin correctly, and the result will be hyperglycemia.


The researchers fed mice with two different diets, the ketogenic diet and the high-fat diet, which led to liver resistance to insulin, followed by standardized metabolic experiments to explore the effects of insulin during animal development. The effect of sugar (mainly liver) and tissue (mainly muscle) on sugar absorption.


It was found that although the ketogenic diet-fed animals appeared healthy in the fasted state, they exhibited decreased glucose tolerance compared to high-carbohydrate, high-fat, Western-style (HFD)-fed animals. To a greater extent. In addition, it has been found that this effect is not caused by glucose clearance or impaired tissue glucose uptake, but because insulin inhibits hepatic glucose production. Data analysis showed that the early effects of HFD intake on endogenous glucose may be part of the normal physiological response to increased lipid uptake and oxidation, and that systemic insulin resistance is due to the addition of dietary glucose to EGP-derived glucose. To.

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Therefore, the researchers concluded that the ketogenic diet controls abnormal blood glucose levels and that insulin resistance exists in the liver. This may increase type 2 diabetes when the liver is unable to respond to normal levels of insulin to control blood glucose levels. risk. At the same time, the researchers also said that the mouse experiment has certain limitations, so it is only possible to infer how the short-term ketogenic diet affects human health. The future plan is to further conduct human experimental research. In addition, the study did not analyze whether long-term ketogenic diets lead to obesity, and the underlying mechanisms need to be discussed; whether there is a common physiological response between low-carbohydrate and conventional high-fat carbohydrate diets, thereby causing insulin resistance in the liver. Further research is needed.

Weight loss VS diabetes

In recent months, the low-carbohydrate-based ketogenic diet has soared, and it has set off a fat-reducing climax. For this phenomenon, "World Foods" magazine recently published an article to explore this trend and other weight loss strategies from the perspective of several dietitians.


Nutritionist Sharon Palmer said that although the ketogenic diet is very popular, there is no evidence that it is good for health, but this epidemic will expel many healthy foods, such as whole grains, fruits, vegetables and beans, one-sided Pursuing a strict proportion of protein, carbohydrates and fats, long-term, some essential nutrients such as vitamins, minerals, fiber and plant matter will be lacking. In addition, whether ketosis is the ideal state of long-term existence of the body, and there is no known, the most healthy and effective way to lose weight is to stick to the diet for a long time.


Kirsty Barrett, a registered dietitian and spokesman for the British Dietetic Association (BDA), believes that although there is evidence that the ketogenic diet does promote weight loss, it is no better than some other diets. People may be more inclined to foods that help increase satiety, such as high-fat, high-protein foods, and some low-carbohydrate-rich vegetables such as fiber. The eating habits of ancient people were more inclined to the ketogenic diet, because in ancient times, many of the foods promoted were part of a low-carb diet.