Tianeptine

Product Name: Tianeptine
CAS: 1224690-84-9
Appearance: Off-white to white powder
Grade: Pharmaceutical grade
All types: Tianeptine; Tianeptine Sodium; Tianeptine sulfate
MF: C21H24ClN2NaO4S

  • Description
  • Packing
  • Tianeptine

    Tianeptine is an atypical antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. In terms of chemical structure, it is technically a tricyclic antidepressant (TCA), but it has a very different drug profile than other TCAs, and is not usually grouped with them.

    Tianeptine has antidepressant and anxiolytic effects with a relative lack of sedative, anticholinergic, and cardiovascular side effects. It has been found to act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors. μ-Opioid receptor agonists typically induce euphoria, and in accordance, tianeptine does so at high doses well above the normal therapeutic range.


    Product Name: Tianeptine

    CAS: 1224690-84-9

    Appearance: Off-white to white powder  

    Grade: Pharmaceutical grade

    All types: Tianeptine; Tianeptine Sodium; Tianeptine sulfate

    MF: C21H24ClN2NaO4S




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    Tianeptine's Analysis Sheet:

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      Functions of Tianeptine:   

    Depression and anxiety

    Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas (carbogen) on paroxetine or tianeptine therapy showed equivalent panic-blocking effects. Like many antidepressants (including bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition in people with depression-induced cognitive dysfunction.

    Tianeptine has been found to be effective in depression in Parkinson's disease and in post-traumatic stress disorder of which it was as safe and effective as fluoxetine and moclobemide. A clinical trial has been conducted to compare its efficacy and tolerability with amitriptyline in the treatment of irritable bowel syndrome. The results of this trial showed that tianeptine was at least as effective as amitriptyline and produced less prominent adverse effects such as dry mouth and constipation.

    Tianeptine has been reported to be very effective for asthma. In August 1998, Dr. Fuad Lechin and colleagues at the Central University of Venezuela Institute of Experimental Medicine in Caracas published the results of a 52-week randomized controlled trial of asthmatic children; the children in the groups that received tianeptine had a sharp decrease in clinical rating and increased lung function. Two years earlier, they had found a close, positive association between free serotonin in plasma and severity of asthma in symptomatic personsAs tianeptine was the only agent known to both reduce free serotonin in plasma and enhance uptake in platelets, they decided to use it to see if reducing free serotonin levels in plasma would help. By November 2004, there had been two double-blind placebo-controlled crossover trials and a >25,000 person open-label study lasting over seven years, all showing effectiveness. A 2005 study in Egypt demonstrated tianeptine to be effective in men with depression and erectile dysfunction. Tianeptine also has anticonvulsant and analgesic effects and a clinical trial in Spain that ended in January 2007 has shown that tianeptine is effective in treating pain due to fibromyalgia. Tianeptine has been shown to have efficacy with minimal side effects in the treatment of attention-deficit hyperactivity disorder.


  • Below 5KG

    Aluminum foil bag inside, carton outside

    Above 6~25KG

    Double sealed PP bags inside, fiber drum outside

    Drum Volume

    25KG Drum: 37cm*37cm*51cm

    10KG Drum: 30cm*30cm*40cm

    Carton Volume

    1KG Carton: 200mm*200mm*260mm

    5KG Carton: 250mm*330mm*270mm

    Remark

    We could pack as your requirements, and OEM & ODM welcome.

     

     

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