Myelin Basic Protein

Prodcut Name: Myelin Basic Protein
Specification: 99%
Appearance: White powder
Mesh Size: 80 Mesh
Grade: Medical Ingredients
Test Method: HPLC

  • Description
  • Packing
  • Myelin Basic Protein

    Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. MBP maintains the correct structure of myelin, interacting with the lipids in the myelin membrane.

    MBP was initially sequenced in 1971 after isolation from myelin membranes. Since that time, knockout mice deficient in MBP that showed decreased amounts of CNS myelination and a progressive disorder characterized by tremors, seizures, and early death have been developed. The human gene for MBP is on chromosome 18; the protein localizes to the CNS and to various cells of the hematopoietic system.

    Prodcut Name: Myelin Basic Protein

    Specification: 99%

    Appearance: White powder

    Mesh Size: 80 Mesh                                 

    Grade: Medical Ingredients

    Test Method: HPLC


        Functions of Myelin Basic Protein     

    Some recent works have shown that inoculating an animal with MBP to generate an immune response against it increases blood–brain barrier permeability.

    A targeted immune response to MBP has been researched in lethal rabies infection. The inoculation of MBP generates increases the permeability of the blood–brain barrier (BBB), allowing immune cells to enter the brain, the primary site of rabies virus replication. In a study of mice infected with Silver-haired bat rabies virus (SHBRV), the mortality rate of mice treated with MBP improved 20%-30% over the untreated control group. It is significant to note that healthy uninfected mice treated with MBP showed an increase in mortality rate between 0% and 40%.

    A "molecular mimicry" hypothesis of multiple sclerosis has been suggested, in which T cells are, in essence, confusing MBP with human herpesvirus-6. Researchers in the United States created a synthetic peptide with a sequence identical to that of an HHV-6 peptide. They were able to show that T cells were activated by this peptide. These activated T cells also recognized and initiated an immune response against a synthetically created peptide sequence that is identical to part of human MBP. During their research, they found that the levels of these cross-reactive T cells are significantly elevated in multiple sclerosis patients.


  • Below 5KG

    Aluminum foil bag inside, carton outside

    Above 6~25KG

    Double sealed PP bags inside, fiber drum outside

    Drum Volume

    25KG Drum: 37cm*37cm*51cm

    10KG Drum: 30cm*30cm*40cm

    Carton Volume

    1KG Carton: 200mm*200mm*260mm

    5KG Carton: 250mm*330mm*270mm

    Remark

    We could pack as your requirements, and OEM & ODM welcome.

     

     

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